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HPV、EBV、HBV捕獲測序

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產品簡介

產品簡介:

        病毒是目前發現的最小病原體,由于能夠誘發細胞癌變,所以又被稱為病毒致癌因子,屬于三種致癌因子之一。病毒誘發人體細胞癌變的主要機制是將自身基因組整合進入人的基因組中。
        同一種病毒的不同亞型的感染,病毒基因組的突變,以及病毒基因組在人類基因組上整合位置的不同都會對患者的病理進程、治療效果以及預后產生影響。因此,對于致癌病毒的基因組研究應該涵蓋亞型識別,突變以及整合位點檢測三個方面。ViralCap HPV


ViralCap病毒基因組捕獲系列產品 

 

類型 檢測亞型 研究對象
ViralCap HPV 6,11,16,18,31,33,35,39,45,51,52,56,58,59,66,68,69,82等32種主要亞型 宮頸癌、食管癌,以及由HPV侵染引起的癌癥患者
ViralCap EBV 全EBV基因組(~180k)捕獲,覆蓋4WT,AG876,B95-8,GD1,GD2,HKNPC1等24種亞型 鼻咽癌、淋巴瘤、胃癌,以及由EBV侵染引起的癌癥患者
ViralCap HBV A,B,C,D,E,F,G,H 8種亞型 肝癌,以及受HBV侵染的癌癥患者


產品優勢:

◆ 病毒分型、突變以及整合分析同時完成
◆ 靈敏度可達0.05%
◆ 和全基因組測序相比,有效降低測序成本
◆ 適合大樣本量驗證

生物信息分析:

 
     標準化分析 HBV、HPV、EBV Genomic Alignment, Genotyping, Integration;
SNP;  InDel
     個性化分析  Evolution Analysis[病毒進化分析]; New Gene Prediction
 
測序策略:100PE, 125PE,150PE,平均測序深度: 500X

項目周期:30個工作日——捕獲測序(自樣本質控合格之日起,不包括數據分析),附加5~15個工作日進行數據分析。

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