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腫瘤

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產品簡介:
         肺癌靶向藥物能瞄準特定的肺癌細胞,并在目標部位蓄積或釋放有效成分,通常肺癌靶向藥物具有高度的選擇性。多數實驗結果表明,在使用肺癌靶向藥物前,對肺癌患者進行腫瘤靶向用藥的個體化分析,選擇最適合肺癌患者的靶向藥物,提高對藥物的敏感性,從而避免過度治療,提高患者生活質量。
        邁基諾通過與肺癌科研專家攜手,針對腫瘤分子分型設計特異性的捕獲方案,并結合新一代
分析技術和生物信息學分析,對目標腫瘤進行基因分析。從而在科學層面上為肺癌患者的靶向用藥提供合理的科學依據。

 
肺癌靶向用藥panel包含8種基因突變情況
              
 
技術優勢:
        1、獨立的設計專利:NGS+MygenoCap技術平臺,國內一家擁有獨立基因捕獲技術知識產權,可以自己不斷優化捕獲流程,也可以個性化定制捕獲試劑盒;
        2、強大的研發能力:不斷根據廣大研究者的需求研發出更貼近于分析疾病的項目;
        3、精確的數據質量:捕獲深度可達500X,覆蓋度高度99% 以上;
        4、全面的分析結果:可一次性分析到單個堿基置換、堿基插入缺失、片段的缺失重復、染色體變異等,結果更全面準確。


技術流程:
圖1 腫瘤系統基因捕獲實驗流程
 
應用實例:
    適用人群:
        1、對肺癌腫瘤基因實現分子分型,明確肺癌突變類型;
        2、輔助科研人員制定合理的治療方案;
        3、為亞健康人群及健康人群進行風險預測和評估,提供后期的預防保健咨詢。
    實例描述:
      成功案例*
        某某,女,45歲,有8年的吸煙史,無家族史,檢查結果:
         1.CT顯示患者左側肺部有大小為3.1x3.4CM2的腫塊;
         2.活檢顯示轉移性腺癌;
         3.無EGFR和KRAS突變;
         4.FISH陰性,IHC陽性。


      分析方法:
         MygenoCap+NGS


      分析結果:
         圖A 所示,IHC結果為陽性;如圖B所示, FISH結果為陰性(非小細胞肺癌FISH判斷依據:兩個熒光信號源融合或者粘則認為是陰性結果);圖C所示,患者腫瘤組織通過邁基諾OncoCap技術,發現了ALK的新融合BIRC6和ALK和BIRC6基因上兩個斷裂點間約3MB的臂內染色體倒位,該結果導致了ALK的高表達。

 

注* :文章題目“BIRC6-ALK, a Novel Fusion Gene in ALK Break-Apart FISH-Negative Lung Adenocarcinoma, Responds to Crizotinib”

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